NOBEL-DÍJASOK ÉS TEHETSÉGES DIÁKOK XVI. TALÁLKOZÓJA
2021. április 8-9.
Üdvözöljük konferenciánkon!
Ez alkalommal sajnos nem köszönthetjük Önöket Szeged gyönyörű városában, a konferencia teljes egészében online kerül megrendezésre!
Programfüzet
Ismerje meg a konferencia programját!
KONFERENCIA VIDEÓ LINKEK
Nézze vissza a konferencia előadásait!
Díszvendégek
Ismerje meg a konferencia kiemelt vendégeit!
Bert Sakmann
Nobel-díjas német fiziológus
1991-ben Erwin Neher-rel együtt elnyerte az orvostudományi Nobel-díjat a sejtek egyedi ioncsatornáinak működését illető felfedezéseiért és a folt-feszültségzár (patch clamp) méréstechnika kidolgozásáért.
Sir Richard Timothy Hunt
Nobel-díjas angol biokémikus
2001-ben Paul Nurse-szel és Leland H. Hartwell-lel megosztva elnyerte az orvostudományi Nobel-díjat a sejtciklus szabályozását végző fehérjék felfedezéséért.
Meghívott előadók
Ismerje meg a konferencia előadóit!
Előadók
Vida Noémi
Szegedi Tudós Akadémia, II. évf.
Szegedi Tudományegyetem,
Általános Orvostudományi Kar, II. évf.
Modeling VV-ECMO induced inflammatory reaction in large animal
2021. április 8.
Extracorporeal membrane oxygenation (ECMO) is usually used as an intensive care therapy method, when the lungs or the heart as well requires external help to restore normal oxygenation.
Our main goal in this experiment was to analyse the process of deterioration of microcirculation and mitochondrial functions in a clinically relevant large animal model. We would like to map out the exact pathomechanism behind ECMO induced inflammation in the clinical setting. Examining these components would lay down the foundation of a novel therapy’s development, which could aid the protection of organ barriers during ECMO usage. We created a large animal model, which can endure a 30-hour anaesthesia and is susceptible to represent ECMO induced inflammatory responses. With the data gained we can demonstrate the decline in microcirculatory activity and worsened mitochondrial function, thus the decreased function in mucous membrane barrier through time.
Asztalos Leó
Szegedi Tudós Akadémia, IV. évf.
Szegedi Tudományegyetem,
Általános Orvostudományi Kar, V. évf.
When less is more - generalist HLA alleles and antitumor immunity
2021. április 8.
The immune system is fundamental in eliminating pathogens and tumorous cells. Our research group investigates the HLA molecules, which play a central role in immune recognition.
These molecules present protein-sequences to the immune system, which can be from pathogens, mutated tumour proteins or harmless proteins from our own cells. There are many different HLA molecules, therefore two individuals potentially carry different variants. The different HLA variants can present different protein-sequences, and this genetic variability affects how susceptible we are to infectious, autoimmune and tumorous diseases. During our research we noticed an interesting phenomenon: In tumours it is not always beneficial if the HLA molecules present many different mutant proteins. Contrary, in this case the anti-tumor immune response of these patients is insufficient. Our results can help to decide which patients will potentially respond to immunotherapy and which ones should be treated with other therapies.
Tóth Dávid
Szegedi Tudós Akadémia, VI. évf.
Szegedi Tudományegyetem,
Általános Orvostudományi Kar, VI. évf.
Analysis of SARS-CoV-2 and mAtg8 proteins interaction in MCF-7 cells
2021. április 8.
The members of Nidovirales order (MHV, SARS and MERS) form double-membrane vesicles (DMVs) in infected cells and isolate replication-transcription complexes, thus using host cell membranes for their own replication.
The mAtg8 is a key protein of DMVs formation. The mAtg8 interactor proteins connect to mAtg8 through LIR motif. Our overarching aim was to identify novel host factors that may interact with SARS-CoV-2 proteins and to understand the biological importance of LIR motifs on SARS-CoV-2 proteins. 10 LIR motif containing SARS-CoV-2 proteins were predicted with databases and software. The predicted proteins were expressed with marked mAtg8 proteins and endogenous mAtg8. Most of the predicted interactions via bioinformatics approaches were experimentally testified with microscopy. One of the coronavirus proteins formed membrane rearrangements (so-called edemosomes). Our analysis characterized the mechanism and regulators of this phenomenon.
Gyulai-Nagy Szuzina
Szegedi Tudós Akadémia, V. évf.
Szegedi Tudományegyetem,
Általános Orvostudományi Kar, V. évf
Multiple roles of exosomes in cell migration
2021. április 8.
Intercellular communication is crucial in the survival of multicellular organisms, which can be mediated by the intercellular transport of exosomes.
The exosomes are phospholipid-bilayered extracellular vesicles with diameter of 20-100 nm, and they modulate cell migration. In our experiments, we used myoblasts (skeletal muscle cells) and carried out live-cell microscopy, we isolated exosomes, studied their uptake, and performed super-resolution microscopy. We analysed the images by several image analysis programmes. The migration parameters were significantly increased by the isolated exosome fraction; furthermore, the exosomes are taken up by the myoblasts and they show polarized intracellular distribution in the migrating cells. Our observations could also describe the migration of other cell types, while the exosomes may have potential clinical application.
Fejes Roland
Szegedi Tudós Akadémia, VI. évf.
Szegedi Tudományegyetem,
Általános Orvostudományi Kar, VI. évf.
Sepsis and therapy - from impaired mitochondria to multiorgan failure
2021. április 8.
According to the latest definition, sepsis is dysregulated host response caused by a confirmed or suspected infection leading to multiple organ failure (MOF).
This condition associated with tissue hypoxia might originate from the mitochondrial-microcirculatory dysfunction syndrome (MMDS), where the oxygen delivery and consumption are deteriorated. Proper therapy for sepsis is still a global challenge for medicine, so there is an increase on demand on MMDS- and MOF-targeted treatments. Our research team developed therapeutic strategies that can directly or indirectly affect MMDS and MOF by inhibiting-activating molecules present in endogenous regulatory system (kynurenic acid) and microcirculatory regulatory receptors (endothelin-1). In our experiments we use a septic rat model, in which the microcirculation is examined by real-time video-microscope imaging, the mitochondrial respiration is measured by high-resolution respirometry, and the severity of MOF is evaluated with a scoring system developed by our team.
Az Év Szent-Györgyi Diákja
Szikra Botond
Ecologycal experiments, and the carbon fixation in
2021. április 9. 10.30-10.45
In 2019 I had to conduct a small ecology research for Kitaibel Pál Biology Competition, and while I was walking by some construction sites, I was wondering what kind of plants could endure such harsh circumstances. So I did my research on the flora of these sites. I counted the species, in order to calculate their diversity. I also measured the pH and nitrate concentrations in the soil of the construction sites, and the particulates in the air. I had read about the fact that stress increases the free amino acid concentrations in plants, and I tried to show this effect with TLC. The durability of plants had arisen my interest for their adaptation to different climates. In the second half of my presentation, I will talk about the different carbon-dioxide incorporation pathways, such as the C3, C4 and CAM mechanisms.
Az Év Talentum-díjasa
Dr. Martinek Tamás
Szegedi Tudományegyetem Orvosi Vegytani Intézet
Intracellular protein delivery with endocytosis routing sequences
2021. április 9. 10.45-11.20
The efficient translocation of macromolecular drugs into cells is a significant challenge in drug development because the mammalian cell membrane acts as a barrier to them.
Our goal was to internalise proteins through clathrin-independent lipid-mediated endocytosis, which avoids the lysosomes and routes to the cytosol. We found a pentapeptide with a high affinity toward an abundant receptor in the lipid rafts, ganglioside GM1, which successfully routed large proteins including antibodies to degradation-free endocytosis. The cell penetration occurred at therapeutically relevant nanomolar concentration, and the proteins remained functionally intact.